Table 1.
Summary of metabolic patterns and liver responses in transgenic mice with a liver-specific expression of the COX-2 gene
| Model #1[38,41] | Model #2[42,43] | Model #3[44,45] | |
| PGE2 WT vs TG | 45 vs 1752 | 30 vs 5502 | 22 vs 581 |
| Challenge | |||
| LPS/D-GalN | Protection | ND | Sensitization |
| MCD/CCl4 | ND | Irrelevant | ND |
| Jo2 (FasL) | Protection | ND | Protection |
| Transaminases after challenge | |||
| WT/TG (UI/L) | 3750/625 | 500/500 | 400/1600 |
| Infiltration3 | No | Yes | ND |
| Fibrosis3 | No | No | No |
| Hepatitis3 | No | Yes | ND |
| HCC-induction3 | ND | ND | ND |
1
pg/mg of liver;
2
pg/mg of protein;
3
In animals aged 12-mo. COX-2: Cyclooxygenase 2; ND: Not determined; PG: Prostaglandin; LPS: Lipopolysaccharide; D-GalN: D-galactosamine; MCD: Methionine and choline-deficient diet model; HCC: Hepatocellular carcinoma; WT: Wild type; TG: COX-2 transgenic mice.