Figure 1.

Effects of Recql5 deficiency in the development of intestinal adenomas in the Apc^Min/+ mice. Recql5^+/+Apc^Min/+ and Recql5^-/-Apc^Min/+ mice were monitored and sacrificed at 90 d of age. A, B: Representative microscopic images of sections from the ileum of a Recql5^+/+Apc^Min/+ (A) and a Recql5^-/-Apc^Min/+ (B) mouse. A microadenoma (diameter < 1 mm, short arrows) and a macroadenoma (diameter ≥ 1 mm, long arrows) are indicated in (A, B); C, D: Multiplicity of macroadenomas (C) and microadenomas (D) in the intestine of individual mice at 90 d of age. Mean and SE are also shown at the top of each column. Each data point represents the total number of macroadenomas (C) or microadenomas (D) in a single mouse.