Figure 5.
Stimulation of BPH1 cells with rhuCCL5 modulates a limited number of genes representing adhesion molecules and regulators of angiogenesis. Figure shows all the genes from 2 separate 96 gene RT PCR pathway arrays (Matrix and Adhesion Molecules and Angiogenesis Promoters and Inhibitors, SA Biosciences) that demonstrate at least a >40% increase or decrease in BPH1 gene expression after stimulation with rhuCCL5 (20ng/ml). Relative to the other pathways, CCL5 induced large changes in transcripts for genes that regulate angiogenesis. Of note, pro-angiogenic molecules that are highly expressed in the prostate are increased in response to CCL5.