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. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: Int J Biochem Cell Biol. 2009 Dec 3;42(2):337–345. doi: 10.1016/j.biocel.2009.11.019

Figure 4. BTP inhibits drebrin function.

Figure 4

A) CHO cells transfected with either GFP (top panel) or GFP-drebrin (middle and bottom panels). Cells were treated with DMSO (vehicle, middle panel) or BTP (bottom panel) prior to staining for F-actin (red) and visualization using confocal laser scanning microscopy. One of 3 similar experiments. B) Jurkat T cells were transfected with either GFP (top panel) or GFP-drebrin (bottom panel). Cells were stained for F-actin (red) and visualized as in (A). One of at least 5 similar experiments. White bar indicate 20 µm. C) Branched cell extensions caused by drebrin over-expression (filopodia-like extensions, FLE) were counted on each cell in DMSO and BTP treated cells and expressed as average FLE per cell, D) the number of cells having a given range of FLEs per cell, E) the average number of branch points per FLE, and F) the average length of each FLE. For all measurements n=25 cells, *p<0.05. One of 3 similar experiments.