Table 4.

Schedule of dosage changes and last reported status at end point

Dose changes (mg/day)
Starting dosage	End point dosage	Progression	No progression	Total
100	400	1		1
200	600	1		1
300	250		1	1
	300		1	1
	400	1		1
400	0	2	2	4
	300	4	1	5
	400	57	16	73
	600	5	6	11
	800	1	1	2
≤ 400 subtotal		72	28	100
600	300	2	1	3
	400	4	2	6
	500		1	1
	600	7	7	14
	800		2	2
600 subtotal		13	13	26
800	0	2		2
	100	1		1
	400	13	5	18
	450	1		1
	500	1		1
	600	6	4	10
	800	6	4	10
800 subtotal		30	13	43
Grand total		115	54	169

Progression includes subjects who reported either tumor progression or death at last follow-up. No progression includes a last report of no evident disease, tumor shrinkage, and stable disease