Figure 2.

Contractions of aorta from nondiabetic and diabetic males and females to serotonin. Contractions to serotonin were greater in aorta from nondiabetic males (a) than females ((b) n = 13–15 per group, P < .05). Following development of diabetes, contractions to serotonin were increased in males ((a) n = 14) but not females ((b) n = 12, *P < .05 nondiabetic versus diabetic). In diabetic males and females inhibition of rho kinase with fasudil (10 μM) reduced contractions to serotonin ((c) males, n = 5, (d) females, n = 8, ^† P < .05 diabetic versus diabetic plus fasudil).