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Effects of chronic treatment with fasudil (100 mg/kg/day, po) on contractions of aorta from nondiabetic and diabetic male mice to serotonin ((a) and (b), resp.). In contrast to effects of acute inhibition of rho kinase, chronic treatment with fasudil increased contractions of aorta from both nondiabetics and diabetics to serotonin (*P < .05 versus untreated). Chronic treatment with fasudil had no effect on contractions to U46619 in aorta from either nondiabetics or diabetics (c).
