Table 2.
Proteins identified in Fraction 27.
| IPI no. | Protein name | Spectral count | Other fractions where protein was found | Description | Previously found in platelets |
|---|---|---|---|---|---|
| IPI00745872.2 | Isoform 1 of serum albumin precursor | 274 | 23–26, 28, 31, 42 | Serum albumin | Yes |
| IPI00022434.4 | Uncharacterized protein alb | 78 | 22–26, 28–43, | Albumin protein | Yes |
| IPI00021439.1 | Actin, cytoplasmic 1 | 20 | 22-23, 25-26, 28–29, 31–33 | Highly conserved cytoskeletal protein involved in cell motility | Yes |
| IPI00298497.3 | Fibrinogen beta chain, precursor | 18 | 23–26, 28, 44 | Yields monomers that polymerize fibrin and act as a cofactor in platelet aggregation | Yes |
| IPI00021891.5 | Isoform gamma-b of fibrinogen gamma chain precursor | 14 | 23–26 | Yields monomers that polymerize fibrin and act as a cofactor in platelet aggregation | Yes |
| IPI00027547.2 | Dermcidin precursor | 15 | 8–26, 28–32, 34, 41, 45 | Antimicrobial activity and survival promoting peptide for neurons | |
| IPI00884222.1 | Similar to keratin, type 1 cytoskeletal 10 | 62 | 32 | Heterotetramer of two type I and two type II keratins | |
| IPI00021841.1 | Apolipoprotein a-i precursor | 3 | 25, 31-32, 34, 44–45 | Participates in reverse transport of cholesterol from tissues to the liver | |
| IPI00013933.2 | Isoform dpi of desmoplakin | 5 | 22, 24, 29–32 | High molecular weight protein of desmosomes | |
| IPI00296099.6 | Thrombospondin-1 precursor | 32 | 26, 28 | Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions | Yes |
| IPI00021885.1 | Isoform 1 of fibrinogen alpha chain precursor | 5 | 23–26, 34 | Cofactor in platelet aggregation and yield monomers that polymerize into fibrin | Yes |
| IPI00478003.1 | Alpha-2-macroglobulin precursor | 13 | 23, 25, 44 | Protease inhibitor | |
| IPI00022445.1 | Platelet basic protein precursor | 12 | 23–26, 28–34 | Precursor for a number of peptides with antimicrobial (TC-1 and TC-2), chemoattractant, and stimulation of DNA synthesis activity | Yes |
| IPI00419424.3 | Igkv1-5 protein | 2 | 23–25, 31, 42, 44–45 | Immunoglobulin | |
| IPI00453473.6 | Histone h4 | 3 | 22-23, 25-26, 30–32, 34, 36 | Core component of nucleosomes playing a central role in DNA repair, replication, and transcription | |
| IPI00783987.2 | Complement c3 precursor (fragment) | 15 | 22, 25 | Involved in activation of the complement system and local inflammation | |
| IPI00026314.1 | Isoform 1 of gelsolin precursor | 14 | 26 | Calcium-regulated, actin-modulating protein | Yes |
| IPI00022434.4 | Uncharacterized protein alb. | 78 | 22–26, 28–43 | Uncharacterized albumin protein | Yes |
| IPI00017601.1 | Ceruloplasmin precursor | 15 | 22 | Glycoprotein involved in iron transport across cell membrane | |
| IPI00382606.1 | Factor vii active site mutant immunoconjugate | 4 | 45 | Initiates extrinsic pathway of blood coagulation | |
| IPI00154742.6 | Igl@ protein | 2 | 24-25, 31 | Immunoglobulin | |
| IPI00550991.3 | Alpha-1-antichymotrypsin precursor | 6 | 44 | Inhibits neutrophil cathepsin G and mast cell chymase | |
| IPI00025252.1 | Protein disulfide-isomerase a3 precursor | 4 | 26 | Catalyses the rearrangement of S-S bonds in proteins | Yes |
| IPI00022431.1 | Alpha-2-hs-glycoprotein precursor | 3 | 44 | Secreted protein, part of the fetuin family, may be involved in differentiation | Yes |
| IPI00032292.1 | Metalloproteinase inhibitor 1 precursor | 3 | Complexes with metalloproteinases and irreversibly inactivates them | Yes | |
| IPI00555812.4 | Vitamin d-binding protein precursor | 1 | 23, 44 | Multifunctional protein found in many body fluids and on the surface of various cell types | Yes |
| IPI00179709.4 | Isoform 1 of tubulin alpha-3c/d chain | 2 | Major constituent of microtubules | ||
| IPI00006114.4 | Proliferation-inducing protein 35/PEDF | 2 | Induces neuronal differentiation and inhibits angiogenesis | Yes | |
| IPI00739464.1 | Similar to cytoplasmic beta-actin | 1 | 31 | Highly conserved cytoskeletal protein involved in cell motility | Yes |
| IPI00414860.6 | 60s ribosomal protein l37a | 1 | Ribosomal protein containing a zinc finger domain, expressed in many cell types | Yes | |
| IPI00020996.3 | Insulin-like growth factor-binding protein complex acid labile chain precursor | 1 | Secreted protein involved in protein complexes with insulin-like growth factor family | ||
| IPI00418471.6 | Vimentin | 1 | Class III intermediate filament protein found in many nonepithelial cells | Yes |