Table 1. Survival of piglets orally-challenged with 1 × 1010 CFU of EHEC strain 933 and treated IP 48 h after challenge with 2 mg of either Stx2-specific HuMAb 5C12 or Stx1-specific HuMAb 5A4.
Treatment | Total no. of piglets | No. (%) of survivors2 | No. (%) died |
---|---|---|---|
PBS1 | 14 | 5 (36) | 9 (64) |
5C12 | 11 | 11 (100) | 0 (0) |
5A4 | 6 | 0 (0) | 6 (100) |
PBS group served as a placebo control.
Survival rates were significantly different (p values: 0.04 for PBS vs 5C12, 0.01 for PBS vs 5A4, and 0.00008 for 5C12 vs 5A4).