Fig. 1.
Significance of individual single nucleotide polymorphisms (SNPs) and sliding window haplotypes for the interferon regulatory factor 6 (IRF6) gene in four groups of nonsyndromic cleft lip with or without cleft palate trios. The −log10 (empirical P value) for the overall χ2 test for an individual SNP (vertical line) and for sliding windows of haplotypes of two to five SNPs (horizontal lines) is presented. Nominal significance levels are denoted by gray lines (5%, 1%, 0.1%, 0.01%, and 0.001%).