Aprotinin concentration was significantly higher (denoted by *) in the double full dose group compared to the standard full dose, low dose, and control at the end of cooling, end of bypass, 3 hours post-CPB (all P < .001), and 12 hours post-CPB (all P < .05). Standard full dose group was significantly higher (denoted by †) than low dose and control group at end of cooling and end of bypass (all P < .01). Low dose group was not significantly different from control group at any time point (all P > .25). Analysis was determined using repeated-measures ANOVA with Bonferroni-adjusted group comparisons.