Table 1.
Median Inhibitory Concentration (IC50) Values of 36 Binding Inhibitors of SIGK with Maximum Value of Less than 300 μM and the Molecular Weight for Each Inhibitor
| compound | MW | IC50 (μM) | compound | MW | IC50 (μM) |
|---|---|---|---|---|---|
| 119910 | 370 | 0.2 | 45382 | 440 | 35.4 |
| 119911 | 314 | 0.2 | 34238 | 402 | 42 |
| 119913 | 394 | 0.7 | 150289 | 464 | 42.5 |
| 51535 | 547 | 2.4 | 88915 | 550 | 47.7 |
| 119889 | 650 | 4.3 | 19630 | 183 | 53.6 |
| 14163 | 414 | 5.9 | 117079 | 473 | 56 |
| 2805 | 246 | 7.1 | 83217 | 407 | 56.9 |
| 118176 | 471 | 8.1 | 17770 | 543 | 59.1 |
| 39207 | 787 | 10.7 | 45126 | 424 | 69.7 |
| 22225 | 387 | 11.4 | 668394 | 452 | 77.7 |
| 12155 | 445 | 24 | 90831 | 560 | 92.9 |
| 9608 | 378 | 16.5 | 117199 | 362 | 161.6 |
| 69343 | 546 | 16.8 | 170423 | 497 | 166.6 |
| 125910 | 566 | 18 | 95676 | 536 | 182.4 |
| 128437 | 477 | 24 | 59275 | 523 | 197.1 |
| 83224 | 136 | 24.9 | 121771 | 260 | 198.1 |
| 14555 | 281 | 26 | 3284 | 512 | 261.9 |
| 23128 | 899 | 27 | 24048 | 442 | 292.1 |