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. Author manuscript; available in PMC: 2010 Mar 29.
Published in final edited form as: Curr Hypertens Rep. 2008 Apr;10(2):99–106. doi: 10.1007/s11906-008-0020-3

Table 1.

Recent mechanistic studies of AngII infusion-induced AAAs in mice.

Category Approach Mouse Effect on AAAs Reference
Strain Gender
RAS components AT1aR -/- : whole body LDLR -/- male [27]
AT1aR -/- : bone marrow
aldosterone apoE-/- [28]
MR antagonism : spironolactone
Inflammation CCR2 -/- : whole body [29]
CCR2 -/- : bone marrow [8,29]
COX-2 -/- hybrid NS [30]
COX-2 inhibition : celecoxib apoE -/- male [31]
COX-1 inhibition : SC-560
5-LO -/- [14]
5-LO inhibition : MK-0591
BLT1 -/- NS [15]
IFN-β male [32]
Proteases HDAC inhibition : MCT-1 [16]
MMP inhibitor: doxycycline LDLR-/- [33]
Oxidative stress p47phox -/- apoE -/- [36]
NOX1 -/- C57BL/6 (N6) [37]
vitamin E apoE -/- [9]
vitamin E and C [35]
Intracellular signaling Rho-kinase inhibition : fasudil [38]
JNK inhibition : SP600125 [13··]
Hormonal Orchidectomy [19]
Ovariectomy female

NS - not stated

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