. Author manuscript; available in PMC: 2010 Mar 29.

Published in final edited form as: Curr Hypertens Rep. 2008 Apr;10(2):99–106. doi: 10.1007/s11906-008-0020-3

Table 1.

Recent mechanistic studies of AngII infusion-induced AAAs in mice.

Category	Approach	Mouse		Effect on AAAs	Reference
Category	Approach	Strain	Gender	Effect on AAAs	Reference
RAS components	AT1aR -/- : whole body	LDLR -/-	male	↓	[27]
	AT1aR -/- : bone marrow	LDLR -/-		↔	[27]
	aldosterone	apoE-/-		↔	[28]
	MR antagonism : spironolactone			↔	[28]
Inflammation	CCR2 -/- : whole body			↓	[29]
	CCR2 -/- : bone marrow			↓	[8,29]
	COX-2 -/-	hybrid	NS	↓	[30]
	COX-2 inhibition : celecoxib	apoE -/-	male	↓	[31]
	COX-1 inhibition : SC-560			↔	[31]
	5-LO -/-			↔	[14]
	5-LO inhibition : MK-0591			↔	[14]
	BLT1 -/-		NS	↓	[15]
	IFN-β		male	↔	[32]
Proteases	HDAC inhibition : MCT-1			↓	[16]
Proteases	MMP inhibitor: doxycycline	LDLR-/-		↓	[33]
Oxidative stress	p47^phox -/-	apoE -/-		↓	[36]
	NOX1 -/-	C57BL/6 (N6)		↓	[37]
	vitamin E	apoE -/-		↓	[9]
	vitamin E and C			↔	[35]
Intracellular signaling	Rho-kinase inhibition : fasudil			↓	[38]
Intracellular signaling	JNK inhibition : SP600125			↓	[13··]
Hormonal	Orchidectomy			↓	[19]
Hormonal	Ovariectomy		female	↔	[19]

NS - not stated