Table 1.
Recent mechanistic studies of AngII infusion-induced AAAs in mice.
Category | Approach | Mouse | Effect on AAAs | Reference | |
---|---|---|---|---|---|
Strain | Gender | ||||
RAS components | AT1aR -/- : whole body | LDLR -/- | male | ↓ | [27] |
AT1aR -/- : bone marrow | ↔ | ||||
aldosterone | apoE-/- | ↔ | [28] | ||
MR antagonism : spironolactone | ↔ | ||||
Inflammation | CCR2 -/- : whole body | ↓ | [29] | ||
CCR2 -/- : bone marrow | ↓ | [8,29] | |||
COX-2 -/- | hybrid | NS | ↓ | [30] | |
COX-2 inhibition : celecoxib | apoE -/- | male | ↓ | [31] | |
COX-1 inhibition : SC-560 | ↔ | ||||
5-LO -/- | ↔ | [14] | |||
5-LO inhibition : MK-0591 | ↔ | ||||
BLT1 -/- | NS | ↓ | [15] | ||
IFN-β | male | ↔ | [32] | ||
Proteases | HDAC inhibition : MCT-1 | ↓ | [16] | ||
MMP inhibitor: doxycycline | LDLR-/- | ↓ | [33] | ||
Oxidative stress | p47phox -/- | apoE -/- | ↓ | [36] | |
NOX1 -/- | C57BL/6 (N6) | ↓ | [37] | ||
vitamin E | apoE -/- | ↓ | [9] | ||
vitamin E and C | ↔ | [35] | |||
Intracellular signaling | Rho-kinase inhibition : fasudil | ↓ | [38] | ||
JNK inhibition : SP600125 | ↓ | [13··] | |||
Hormonal | Orchidectomy | ↓ | [19] | ||
Ovariectomy | female | ↔ |
NS - not stated