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. Author manuscript; available in PMC: 2010 Mar 29.
Published in final edited form as: J Cereb Blood Flow Metab. 2009 Apr 29;29(7):1251–1261. doi: 10.1038/jcbfm.2009.46

Figure 5. ASC neutralization decreases TBI-induced activation and processing of caspase-1, IL-1β, and XIAP cleavage.

Figure 5

Representative immunoblots of injured cortices from animals subjected to TBI and treated intracerebroventricularly with antibodies to ASC (ASC), IgG controls (IgG) or left untreated (Sh) after injury. Animals were sacrificed 24 h after treatment. Treatment resulted in inhibition of inflammasome activation as detected by a decrease in the processing of procaspase-1, IL-1β, and cleavage of XIAP. Anti-ASC treatment also resulted in a significant reduction in caspase-1 activity (right panel). *p < 0.05 vs sham, **p < 0.05 vs IgG.