Table 1. Titration Schedule.

	<40 kg	⩾40 kg
Week	Dose	Dose
Week 0, days 1–4	125 mg po QHS	250 mg po QHS
Week 0, days 5–7	125 mg po BID	250 mg po BID
Week 1, days 1–4	125 mg po QAM, 250 mg po QHS	250 mg po QAM, 500 mg po QHS
Week 1, days 5–7	250 mg po BID	500 mg po BID
Weeks 2–3	Titrated to therapeutic drug levela	Titrated to therapeutic drug levela
Weeks 4–12	Maintained on therapeutic dose	Maintained on therapeutic dose

^aBased on clinical response in conjunction with minimum valproate level (50 μg/ml).