Table 1. List of Genes Regulating Meiosis and Sporulation in S. cerevisiae.

Genes involved in meiosis and sporulation in S. cerevisiae are listed, as well as homologous genes from C. lusitaniae and C. albicans genomes. Although a meiotic program has been identified in C. lusitaniae, functional tests of these putative meiosis genes have not been performed. In the case of C. albicans, a conventional meiosis has not been observed, and several genes that function in meiosis in S. cerevisiae have been shown to have an unrelated function in C. albicans. Homologous genes for C. albicans and C. lusitaniae were identified by the Broad Institute using reciprocal BLAST against S. cerevisiae meiotic and sporulation genes (www.broadinstitute.org). Absence of a homolog is designated as (− ) in this table.

Genes Regulating Meiosis in S. cerevisiae
Function of gene product in S. cerevisiae	S. cerevisiae	C. lusitaniae	C. albicans	Function of gene product in C. albicans
Homeodomain protein that acts with MATα2 to repress mating and permit meiotic induction in a/α diploids.	MATa1	MTLa1	MTLa1	Homeodomain protein that acts with MTLα2 to repress white-phenotypic switching and mating in a/α opaque cells.
Homeodomain protein, promotes α–specific gene expression pattern.	MATα1	CLUG04923	MTLα1	Homeodomain protein, promotes α-specific gene expression patterns.
Homeodomain protein, promotes α-specific gene expression and acts with MATa1 to repress mating and permit meiotic induction in a/α diploids.	MATα2	-	MTLα2	Homeodomain protein that acts with MTLa1 to repress white-opaque phenotypic switching and mating in a/α cells.
Cell type dependent meiotic repressor.	RME1	CLUG05819	orf19.4438	White-phase specific gene expression. Upregulation correlates with clinical resistance to fluconazole, an antifungal.
Methlytransferase required for nutrient sensing and activation of IME1.	IME4	CLUG03093	orf19.1476	No experimental data
Meiotic kinase required for sporulation and activation of IME1.	RIM11	CLUG05114 CLUG01530	orf19.791	No experimental data
Glucose repressed kinase, positive regulator of IME1.	RIM15	CLUG04432	orf19.7044	No experimental data
Serine/threonine kinase important for meiotic entry and chromosome segregation.	MCK1	CLUG01530	orf19.3459	No experimental data
Master transcription factor required for induction of the meiotic pathway.	IME1	-	-
Kinase required for activation of early meiosis genes.	IME2	CLUG00015	orf19.2395	Mutants are hyper-susceptible to the antifungal Amphotericin B.
Transcription factor required for induction of middle-meiosis genes.	NDT80	CLUG00404 CLUG05634	orf19.2119 (orf19.513)	Expression induced by antifungal treatment, required for basal level of antifungal drug tolerance in wild type cells.

Genes Involved in S. cerevisiae Sporulation
Function in S. cerevisiae	S. cerevisiae	C. lusitaniae	C. albicans	Function in C. albicans.
Serine/threonine kinase involved with spore wall formation, expressed at the end of meiosis	SPS1	CLUG04805	orf19.3049	No experimental data
Sporulation specific MAP kinase required for outer spore wall synthesis.	SMK1	CLUG04129	orf19.7208	Putative MAP kinase, mutant produces wrinkled colonies.
Sporulation specific enzyme required for dityrosine synthesis, a cell wall precursor.	DIT1	CLUG03886	orf19.1741	No experimental data
Sporulation specific enzyme required for dityrosine synthesis and cell wall maturation.	DIT2	CLUG02306	orf19.554	Involved with chlamydospore (asexual spore) formation and dityrosine synthesis.
Sporulation specific septin.	SPR3	CLUG04558	orf19.1524	Required for septin formation.
Non-essential protein expressed during sporulation.	SPS4	CLUG05767	orf19.7568	No experimental data