Table 1.
RRMS1 | RRMS2 | RRMS3 | Univariate p value | |
---|---|---|---|---|
No of patients | 116 | 26 | 109 | |
Sex (F/M) | 83/33 | 18/8 | 85/24 | 0.81 |
Age (mean (SD)) | 34.1 (7.5) | 36.7 (7.2) | 34.9 (7.2) | 0.14 |
Disease duration (years from first symptom) (mean (SD)) | 4.9 (3.8) | 10.4 (7.8) | 4.7 (4.0) | 0.002 |
EDSS score (median (interquartile range)) | 2 (1.5, 3.5) | 1.5 (1, 2.5) | 2 (1.5, 3) | 0.006 |
WMV (mm3) (mean (SD)) | 868 423 (85 185) | 827 068 (68 313) | 856 305 (78 411) | 0.021 |
GMV (mm3) (mean (SD)) | 683 707 (70 808) | 693 395 (65 936) | 688 304 (70 588) | 0.51 |
BPV (mm3) (mean (SD)) | 1 552 130 (103 000) | 1 520 463 (95 968) | 1 544 609 (87 652) | 0.14 |
Univariate p values are from Wilcoxon tests comparing RRMS1 and RRMS2; similar p values were obtained from the three group comparison.
BPV, brain parenchymal volume; EDSS, expanded disability status scale; GMV, gray matter volume; RRMS, relapsing–remitting multiple sclerosis; RRMS1, untreated cohort of RRMS patients observed monthly for 9 months14; RRMS2, untreated cohort of RRMS patients observed every 3 months for 1.5 years17; RRMS3, treated cohort of RRMS patients observed monthly for 9 months14; WMV, white matter volume.