. Author manuscript; available in PMC: 2010 Mar 29.

Published in final edited form as: J Neurol Neurosurg Psychiatry. 2009 Feb 9;80(11):1218–1223. doi: 10.1136/jnnp.2008.154732

Table 2.

Volume change estimates from the mixed effects model

	RRMS₁	RRMS₂	RRMS₃
GMV
Annualised % change	−3.57	−1.89	−3.15
σ_ri	0.11	0.078	0.10
σ_rs	0.037	0.040	0.036
ρ_r	−0.13	−0.49	0.24
σ_e	0.023	0.029	0.023
WMV
Annualised % change	1.05	−0.40	1.46
σ_ri	0.093	0.065	0.086
σ_rs	0.035	0.028	0.028
ρ_r	0.12	−0.07	0.11
σ_e	0.022	0.028	0.022
BPV
Annualised % change	−0.94	−1.04	−0.53
σ_ri	0.071	0.063	0.057
σ_rs	0.013	0.015	0.014
ρ_r	−0.17	−0.38	0.12
σ_e	0.0080	0.014	0.0078

Estimated per cent change and variance components for GMV, WMV and BPV from each dataset.

σ_ri is the SD of the random intercept; σ_rs is the SD of the random slope; ρ_r is the correlation between the random intercept and slope; and σ_e is the residual SD. BPV, brain parenchymal volume; GMV, gray matter volume; RRMS, relapsing–remitting multiple sclerosis; RRMS₁, untreated cohort of RRMS patients observed monthly for 9 months¹⁴; RRMS₂, untreated cohort of RRMS patients observed every 3 months for 1.5 years¹⁷; RRMS₃, treated cohort of RRMS patients observed monthly for 9 months¹⁴; WMV, white matter volume.