Table 2.
RRMS1 | RRMS2 | RRMS3 | |
---|---|---|---|
GMV | |||
Annualised % change | −3.57 | −1.89 | −3.15 |
σri | 0.11 | 0.078 | 0.10 |
σrs | 0.037 | 0.040 | 0.036 |
ρr | −0.13 | −0.49 | 0.24 |
σe | 0.023 | 0.029 | 0.023 |
WMV | |||
Annualised % change | 1.05 | −0.40 | 1.46 |
σri | 0.093 | 0.065 | 0.086 |
σrs | 0.035 | 0.028 | 0.028 |
ρr | 0.12 | −0.07 | 0.11 |
σe | 0.022 | 0.028 | 0.022 |
BPV | |||
Annualised % change | −0.94 | −1.04 | −0.53 |
σri | 0.071 | 0.063 | 0.057 |
σrs | 0.013 | 0.015 | 0.014 |
ρr | −0.17 | −0.38 | 0.12 |
σe | 0.0080 | 0.014 | 0.0078 |
Estimated per cent change and variance components for GMV, WMV and BPV from each dataset.
σri is the SD of the random intercept; σrs is the SD of the random slope; ρr is the correlation between the random intercept and slope; and σe is the residual SD. BPV, brain parenchymal volume; GMV, gray matter volume; RRMS, relapsing–remitting multiple sclerosis; RRMS1, untreated cohort of RRMS patients observed monthly for 9 months14; RRMS2, untreated cohort of RRMS patients observed every 3 months for 1.5 years17; RRMS3, treated cohort of RRMS patients observed monthly for 9 months14; WMV, white matter volume.