Fig. 2.
CD147 expression is up-regulated on in vitro-activated CD4+ T cells. PBMCs obtained from human peripheral blood were stimulated in vitro with PHA for 48 h. These activated cells, as well as circulating PBMCs from the same donor, were stained with TC-conjugated anti-CD4 and FITC-conjugated anti-CD147 plus PE-conjugated anti-CD25 or PE-conjugated anti-HLA-DR. Dot plots show expression of CD147 versus CD25 (A) and CD147 versus HLA-DR (B) on circulating and PHA-activated CD4+ T cells. Circled regions denote populations of cells showing CD147bright expression.