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. Author manuscript; available in PMC: 2010 Mar 29.
Published in final edited form as: Eur J Neurosci. 2009 Nov 20;30(11):2143–2150. doi: 10.1111/j.1460-9568.2009.07015.x

Figure 5.

Figure 5

A) T2-weighted image of a FALS mouse with the location and size of the cortical voxel shown (the voxel was 6.5×1.35×2.5mm). B) Representative in vivo spectrum from a FALS mouse with three paralyzed limbs at 140 days of age and an age-matched control. There is a decrease in NAA in the FALS mouse compared to the WT. C) Bar graph showing the effects of motor limb status on the metabolite levels measured at 9.4T (TR/TE 2200/144ms) in vivo in FALS mice from motor cortex. The voxels used here are smaller than those used for the in vitro tissue extraction data reported in Table 1.

* - Denotes significantly different from the animals with no limb paralysis (None). None of the other measured metabolites (Choline or myo-inositol) were significantly different between the groups. There were between 5-7 animals per group. D) Plot of the average NAA values determined in vivo versus those determined in vitro for the same mice. The correlation was highly significant (P < 0.001).