Table 1.

Concentrations of selected MRS visible chemicals for FALS and wild type mice at 84 days of age from in vitro MRS of brain extracts of sensorimotor cortex.

Chemical	Control (n=9)	FALS (n=9)	Change (%)	P values
GABA	34.2 ± 12.9	36.9 ± 5.4		ns
NAA	60.3 ± 14.6	57.3 ± 10.9	-5	ns; p < 0.2
Glutamate	86.1 ± 20.8	111.6 ± 18.6	+30	< 0.05
Glutamine	31.5 ± 13.8	34.8 ± 4.7	+10	ns; p < 0.2
Aspartate	20.6 ± 11.3	27.5 ± 5.6	+33	ns; p < 0.2
Creatine*	60.6 ± 13.8*	64.8 ± 16.4*		ns

Concentrations are expressed as μmol/g protein. Errors reported are standard deviations. P values derive from unpaired t-tests; ns means not significant.

^*Creatine levels were determined from HPLC analysis of the same samples.