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. Author manuscript; available in PMC: 2010 Mar 29.
Published in final edited form as: Cancer Cell. 2008 Feb;13(2):105–116. doi: 10.1016/j.ccr.2007.12.027

Figure 3. Nf1 flox/flox; DhhCre mice show early lethality and develop tumors.

Figure 3

(A) Kaplan-Meyer survival curve. Red, Nf1 flox/flox; DhhCre (n=28); blue, Nf1 flox/+; DhhCre (n=20); green, Nf1 flox/flox (n=9); brown, Nf1 flox/+ (n=8). To facilitate view of control mouse survival, blue green and brown lines are shown offset. (B–F) Gross dissections of tumors and areas of pigmentation in Nf1 flox/flox; DhhCre mice. In gross images B–E, a ruler showing 1mm markings is included. (B) Nf1 flox/flox (wild type) spinal cord from 9 month old mouse, with pairs of spinal roots attached. (C) A similar region from an Nf1 flox/flox; DhhCre mouse, showing three paraspinal GEM-neurofibromas (white arrows) and spinal cord compression. (D, E) Dermal GEM-neurofibromas (white arrows) in Nf1 flox/flox; DhhCre mice in anterior (D) and lateral views (E). (F) Pigmentation was often detected on the surface tumors or adjacent to tumor; a dramatic example is shown. White arrows point to black pigmentation. Bars=1mm.