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Animal trials for cancer therapy using the fabricated RNA nanoparticles. (A) Injection without the pRNA/siRNA chimera (No RNA); (B) Treatment with RNA chimera containing folate-pRNA and siRNA(survivin); (C) Treatment with RNA chimera containing folate-pRNA and siRNA(survivin) with mutations in the siRNA sequence; (D) Treatment with pRNA-siRNA chimera that does not contain a folate at its 5′ end.
