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Electron micrographs of microtubules after incubation with (A) no drug, (B) 50 μM eribulin or (C) 50 μM vinblastine. Ends in controls or eribulin-treated microtubules were either blunt (black triangles) or splayed (white arrows). After incubation with vinblastine, all ends were extensively splayed and many had protruding spiraled protofilaments (black arrows). Magnification 100,000 ×, scale bar 100 nm.
