Table 1.
Jejunal levels of fatty acids in wild-type and CD36-null mice during the dark phase (11:30 pm) and the light phase (11:30 am).
| Dark phase | Light phase | |||
|---|---|---|---|---|
| +/+ | -/- | +/+ | -/- | |
| ω-9 series | ||||
| 18:1 (nmol/g) | 20.17 ± 2.18 | 14.91 ± 1.01*** | 15.07 ± 2.06# | 15.13 ± 1.62 |
| 22:1 (pmol/g) | 594.28 ± 89.72 | 585.99 ± 179.69 | 505.75 ± 111.86 | 734.42 ± 181.62 |
| 24:1 (pmol/g) | 399.9 ± 49.72 | 287.5 ± 87.32 | 318.2 ± 71.55 | 370.9 ± 44.71 |
| ω-6 series | ||||
| 18:2 (nmol/g) | 18.90 ± 2.58 | 15.89 ± 1.33 | 12.71 ± 1.34# | 14.25 ± 1.29 |
| 18:3 (nmol/g) | 3.44 ± 0.42 | 2.48 ± 0.22 | 1.55 ± 0.23### | 1.99 ± 0.24 |
| 20:4 (nmol/g) | 4.41 ± 0.27 | 5.58 ± 0.72 | 4.31 ± 0.24 | 5.77 ± 0.91 |
| Σ ω-6 (nmol/g) | 24.98 ± 2.34 | 21.46 ± 1.95 | 17.02 ± 1.47 | 20.02 ± 1.20 |
| ω-3 series | ||||
| 16:1 (pmol/g) | 2.31 ± 0.18 | 2.06 ± 0.44 | 2.20 ± 0.511 | 3.51 ± 0.59 |
| 20:5 (pmol/g) | 1391.35 ± 140.48 | 1032.78 ± 85.66 | 733.22 ± 52.70### | 857.73 ± 139.40 |
| 22:5 (pmol/g) | 45.48 ± 5.41 | 52.46 ± 10.01 | 44.26 ± 5.78 | 66.52 ± 9.16 |
| 22:6 (nmol/g) | 2.52 ± 0.19 | 2.65 ± 0.35 | 2.52 ± 0.19 | 3.21 ± 0.29 |
| Σ ω-3 (nmol/g) | 51.71 ± 5.74 | 58.21 ± 10.81 | 49.71 ± 6.34 | 73.39 ± 9.80 |
| Saturated | ||||
| C16:0 (nmol/g) | 11.28 ± 0.89 | 9.71 ± 0.83 | 10.44 ± 0.96 | 10.37 ± 0.91 |
| C18:0 (nmol/g) | 11.66 ± 0.83 | 9.36 ± 0.75* | 10.24 ± 0.26 | 9.36 ± 0.61 |
| Σ saturated (nmol/g) | 23.21 ± 1.56 | 19.07 ± 1.49 | 20.68 ± 0.97 | 19.73 ± 1.38 |
| Ratios | ||||
| 16:1/16:0 | 5.08 ± 0.43 | 5.12 ± 0.65 | 5.40 ± 0.70 | 3.41 ± 0.60 |
| 18:1/18:0 | 1.83 ± 0.12 | 1.60 ± 0.07 | 1.48 ± 0.21 | 1.64 ± 0.20 |
| 18:2/18:3 | 6.01 ± 0.18 | 6.42 ± 0.19 | 8.46 ± 0.45 | 7.34 ± 0.47 |
| 20:4/22:6 | 1.77 ± 0.10 | 2.13 ± 0.16 | 1.72 ± 0.07 | 1.77 ± 0.19 |
| 22:1/24:1 | 1.47 ± 0.11 | 1.58 ± 0.31 | 1.60 ± 0.06 | 1.51 ± 0.06 |
| ω-6/ω-3 | 0.49 ± 0.03 | 0.40 ± 0.05 | 0.36 ± 0.03 | 0.28 ± 0.02 |
Data are expressed as mean ± S.E.M of n = 4-5. +/+: wild-type; -/-: CD36-null mice. ω-9 series: 18:1, oleic acid; 22:1, erucic acid and 24:1, nervonic acid; ω-6 series: 18:2, linoleic acid; 18:3, linolenic acid and 20:4, arachidonic acid. ω-3 series: 16:1, palmitoleic acid; 20:5, eicosapentaenoic acid; 22:5, docosapentaenoic acid and 22:6, docosahexaenoic acid; Saturated: C16:0, palmitic acid and C18:0, stearic acid.
*
P < 0.05 and
***
P < 0.005 vs. wild-type within the same phase of the light/dark cycle;
#
P < 0.05 and
###
P < 0.005 vs. dark phase within the same genotype (Two-way ANOVA followed by SNK).