Figure 5.

BDNF^2L/2LCk-cre conditional mutants exhibit deficits in evoked release of dopamine in the dorsal striatum. *p < 0.01. A, Representative amperometric traces of electrical stimulation-evoked dopamine release in acute coronal striatal slices from wild-type (WT) and BDNF^2L/2LCk-cre conditional mutant (CM) mice. Stimulation electrodes and carbon fiber recording microelectrodes were positioned in the medial–dorsal region of the striatum. Data were acquired at 50 kHz and digitally postfiltered at 1 kHz. The arrow points to onset of electrical single pulse (2 ms of 0.5 mA). B, Mean evoked dopamine molecules in the dorsal striatum of wild-type and BDNF^2L/2LCk-cre conditional mutant mice in ACSF and ACSF with the dopamine reuptake inhibitor nomifensine. *p < 0.01. C, Evoked dopamine signal amplitude in the dorsal striatum of wild-type and BDNF^2L/2LCk-cre mutant mice. *p < 0.01. D, Evoked dopamine signal width in the dorsal striatum of wild-type and BDNF^2L/2LCk-cre mutant mice. *p < 0.01.