Figure 1.

Targeting of glioma by radiolabeled chimeric monoclonal antibody directed against the EGFRvIII tumor antigen. (A–C) Planar images of the head and neck obtained on day 0 (A), day 3 (B), and day 7 (C) after infusion of ¹¹¹In‐ch806. Initial blood pool activity is seen on day 0, and uptake of ¹¹¹In‐ch806 in an anaplastic astrocytoma in the right frontal lobe is evident by day 3 (arrow) and increases by day 7. (D–F) Tumor‐specific uptake of ¹¹¹In‐ch806 (arrow) is demonstrated in a SPECT image of the brain (D), ¹⁸F‐FDG (FDG, Fluorodeoxyglucose) positron emission tomography (E) and MRI (F). Figure reproduced with permission from reference (90).