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. Author manuscript; available in PMC: 2010 Mar 29.
Published in final edited form as: J Am Stat Assoc. 2009 Dec 1;104(487):1168–1178. doi: 10.1198/jasa.2009.tm07494

Table 1.

Summary of the simulation results including bias and mean squared error (MSE) for the MLE estimator α̂ and β̂, where ζ is the mean inter-examination time, n is the sample size, and the true values are α0 and β0.

ζ = 0.2 ζ = 0.5


α̂ β̂ α̂ β̂




n α0 β0 Bias MSE Bias MSE Bias MSE Bias MSE
50 0.0 0.0 −0.007 0.043 0.010 0.113 0.023 0.042 −0.012 0.122
0.5 0.002 0.040 0.032 0.120 0.036 0.043 0.044 0.133
1.0 −0.003 0.043 0.042 0.136 0.052 0.055 0.133 0.174
1.0 0.0 0.031 0.040 0.004 0.073 0.087 0.046 −0.002 0.125
0.5 0.042 0.042 0.021 0.092 0.110 0.055 0.113 0.152
1.0 0.030 0.048 0.037 0.093 0.116 0.069 0.165 0.151

100 0.0 0.0 −0.009 0.019 0.011 0.053 0.023 0.019 −0.014 0.058
0.5 0.005 0.020 0.011 0.057 0.027 0.020 0.038 0.063
1.0 0.004 0.019 0.021 0.056 0.041 0.026 0.103 0.082
1.0 0.0 0.018 0.022 −0.007 0.034 0.067 0.023 −0.012 0.058
0.5 0.021 0.019 0.012 0.038 0.078 0.026 0.089 0.086
1.0 0.012 0.022 0.020 0.043 0.070 0.024 0.098 0.056

200 0.0 0.0 −0.006 0.009 0.004 0.025 0.024 0.010 −0.003 0.028
0.5 0.002 0.009 0.007 0.027 0.026 0.010 0.034 0.032
1.0 0.001 0.011 0.011 0.028 0.042 0.013 0.085 0.045
1.0 0.0 0.003 0.010 0.002 0.017 0.054 0.012 −0.028 0.026
0.5 0.008 0.009 0.006 0.018 0.066 0.014 0.074 0.057
1.0 0.005 0.010 0.009 0.020 0.053 0.011 0.061 0.023

NOTE: MSE was the empirical mean-squared error. The average standard errors of MSE for (α̂, β̂) were (0.036, 0.087) when ζ = 0.2, and were (0.048, 0.128) when ζ = 0.5.