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RHOA and PRKCZ cell permeable inhibitory peptides. A: Site organization of RHOA and PRKCZ showing the effector regions of RHOA (aa 23-40, 75-92 and 92-119), and the inhibitory pseudosubstrate region of PRKCZ (aa 113-129). B: Representation of the the plasma membrane translocating peptides. The 23-40 RHOA effector region was fused to Penetratin-1 (left). A myristic acid was added at the N-terminal of the pseudosubstrate region of PRKCZ (right).
