Table 2.
Functional Polymorphism of MMP-1(-16071G/2G), MMP-2 (-1306 C>T), MMP-3 (-1171 5A/6A) MMP-9 (P574R C>G;-1562 C>T) and TIMP-2 (-418 GC or CC) in potentially malignant and malignant head- and neck malignancies
| Study | Country | Year | MMPs type | Mode of detection | Polymorphism | Case/Control group | OR | 95%CI | p-value | Tumour |
|---|---|---|---|---|---|---|---|---|---|---|
| Chaudhary et al [57] | India | 2010 | MMP-3 | PCR-RFLP | -1171 5A/6A | 101/126 135/126 |
2.26 1.94 |
1.22-4.20 1.06-3.51 |
0.01 0.03 |
HNSCC OSMF |
| Shimizu et al [36] | Japan | 2008 | MMP-1 IL-8 | PCR-RFLP, IHC | -1607 1G/2G IL-8-251 A/A |
- |
- - |
- - |
0.001 0.003 |
TSCC |
| Wu et al [61] | China | 2008 | MMP-9 | PCR-RFLP | P574R C>G | - | 4.1 | 1.58-10.52 | 0.00 | ESCC |
| Tu et al [62] | Taiwan | 2007 | MMP-9 | PCR-RFLP | -1562 C>T | 192/191 73/191 |
- | - | 0.029 | OSCC OSMF |
| Nasr et al [38] | North Africa | 2007 | MMP-9 MMP-1 |
PCR-RFLP | -1562 C/T -1607 1G/2G |
174/171 |
- 2.9 |
- |
- 0.02 |
- NPC |
| Vairaktaris et al [63] | Greece | 2008 | MMP-9 | PCR-RFLP | -1562 C/T | 152/162 | 1.9 | 1.21-3.06 | 0.05 | OSCC |
| Vairaktaris et al [55] | Greece | 2007 | MMP-3 MMP-1 |
PCR-RFLP | -1171 5A/6A -1607 1G/2G |
160/156 141/156 |
2.2 - |
1.0-4.5 - |
< 0.05 < 0.05 |
OSCC |
| Nishizawa et al [37] | Japan | 2007 | MMP-1 MMP-3 |
PCR-RFLP | -1607 1G/2G -1171 5A/6A |
170/164 | 2.4 - |
1.5-4.6 - |
0.000 - |
OSCC |
| O-Charoenrat and Khantapura [51] | Thailand | 2006 | TIMP-2 MMP-2 |
PCR-RFLP | -418GC or CC -1306C-->T |
239/250 239/250 |
1.43 1.97 |
0.98-2.08 1.23-3.15 |
- - |
HNSCC |
| Tu et al [56] | Taiwan | 2006 | MMP-3 | PCR-RFLP | -1171 5A/6A | 150/98 71/98 |
1.7 2.62 |
0.84-3.445 1.20-5.71 |
0.18 0.01 |
OSCC OSF |
| Cao and Li [41] | China | 2006 | MMP-1 | PCR-RFLP | -1607 1G/2G | 96/120 | 2.2 | 1.5-3.4 | 0.000 | OSCC |
| Zinzindohoue et al [42] | France | 2004 | MMP-1 MMP-3 |
PCR-RFLP | -1607 1G/2G -1171 5A/6A |
126/249 | 0.37 - |
0.2-0.7 - |
0.003 - |
HNSCC |
| Lin et al [52] | Taiwan | 2004 | MMP-2 | PCR & dHPLC | -1306 C>T | 121/147 58/147 |
2.0 | - | - | OSCC OSF |
| Hashimoto et al [44] | Japan | 2004 | MMP-1 MMP-3 |
PCR-RFLP | -1607 1G/2G -1171 5A/6A |
140/223 | 1.6 NS |
- - |
0.04 NS |
HNSCC |
[PCR-RFLP = Polymerase chain reaction-fragment length polymorphism, dHPLC = Denaturing high-performance liquid chromatography, ESCC = Esophageal squamous cell carcinoma, BSCC = Buccal squamous cell carcinoma, OSCC = Oral squamous cell carcinoma, OSMF = Oral sub-mucous fibrosis, NPC = Nasopharyngeal carcinoma, HNSCC = Head and neck squamous cell carcinoma, TC = Tongue squamous cell Carcinoma, NS = Not significant]