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Cytological and histological examination of biopsy. A) Smear slide showing amyloid (metachromatic, purple) around a capillary (toluidin blue stain), B) paraffin-embedded material: extensive amyloid deposition around capillaries in cortex (Aβ immunoreaction), C) reactive gliosis and upregulation of microglia and macrophages in grey matter, D) reactive gliosis, upregulation of microglia and presence of macrophages in white matter (C and D, HLA-DR (CR3/43) immunoreaction).
