Figure 7. GSH1 overexpression suppresses NFV-induced cell death in parasites.

Stably transfected L. infantum strains carrying either the empty control vector Pspαzeoα (i.e. Li-pSP) or the GSH1-encoding vector PspαzeoαGSH1 were exposed to NFV (40 µM) for 24 h. Cell death was measured in terms of DNA degradation. Light gray bars refer to untreated parasites, whereas black bars relate to NFV-treated parasites (n = 3) (***, P<0.001).