Table 2. Hazard ratios (HR) and 95% confidence intervals (95% CI) for associations between baseline C-reactive protein and interleukin-6 concentrations (by quartiles) and prostate cancer risk1.
No. Cases/cohort | Total Person-Years | HR2 | 95% CI2 | |
---|---|---|---|---|
CRP (mg/l) | ||||
<1.10 | 46 | 4673 | 1.00 | Ref |
1.10-2.11 | 59 | 4572 | 1.27 | 0.86-1.87 |
2.11-3.47 | 55 | 4332 | 1.29 | 0.87-1.91 |
>3.47 | 42 | 4024 | 1.03 | 0.67-1.57 |
Log(CRP) | 1.02 | 0.85-1.21 | ||
IL-6 (mg/l) | ||||
<1.23 | 51 | 4668 | 1.00 | Ref |
1.23-1.69 | 57 | 4256 | 1.24 | 0.84-1.83 |
1.69-2.47 | 45 | 3800 | 1.17 | 0.78-1.76 |
>2.47 | 32 | 3624 | 0.90 | 0.57-1.40 |
Log(IL-6) | 0.97 | 0.74-1.27 | ||
Excluding cases diagnosed in first 5 years | ||||
CRP (mg/l) | ||||
<1.10 | 17 | 4107 | 1.00 | Ref |
1.10-2.11 | 25 | 4188 | 1.38 | 0.74-2.56 |
2.11-3.47 | 18 | 4099 | 0.98 | 0.50-1.92 |
>3.47 | 17 | 3975 | 1.06 | 0.54-2.10 |
Log(CRP) | 1.01 | 0.76-1.36 | ||
IL-6 (mg/l) | ||||
<1.23 | 19 | 4010 | 1.00 | Ref |
1.23-1.69 | 28 | 3862 | 1.61 | 0.89-2.90 |
1.69-2.47 | 14 | 3726 | 0.83 | 0.41-1.70 |
>2.47 | 14 | 3597 | 0.98 | 0.48-1.98 |
Log(IL-6) | 0.84 | 0.54-1.29 |
Excluding individuals with baseline CRP >10 mg/l
Adjusted for age, race, enrollment period, diabetes status, current NSAID use, and clinic