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. Author manuscript; available in PMC: 2010 Sep 1.
Published in final edited form as: Cancer Causes Control. 2009 Mar 8;20(7):1193–1203. doi: 10.1007/s10552-009-9320-4

Table 2. Hazard ratios (HR) and 95% confidence intervals (95% CI) for associations between baseline C-reactive protein and interleukin-6 concentrations (by quartiles) and prostate cancer risk1.

No. Cases/cohort Total Person-Years HR2 95% CI2
CRP (mg/l)
 <1.10 46 4673 1.00 Ref
 1.10-2.11 59 4572 1.27 0.86-1.87
 2.11-3.47 55 4332 1.29 0.87-1.91
 >3.47 42 4024 1.03 0.67-1.57
 Log(CRP) 1.02 0.85-1.21
IL-6 (mg/l)
 <1.23 51 4668 1.00 Ref
 1.23-1.69 57 4256 1.24 0.84-1.83
 1.69-2.47 45 3800 1.17 0.78-1.76
 >2.47 32 3624 0.90 0.57-1.40
 Log(IL-6) 0.97 0.74-1.27

Excluding cases diagnosed in first 5 years

CRP (mg/l)
 <1.10 17 4107 1.00 Ref
 1.10-2.11 25 4188 1.38 0.74-2.56
 2.11-3.47 18 4099 0.98 0.50-1.92
 >3.47 17 3975 1.06 0.54-2.10
 Log(CRP) 1.01 0.76-1.36
IL-6 (mg/l)
 <1.23 19 4010 1.00 Ref
 1.23-1.69 28 3862 1.61 0.89-2.90
 1.69-2.47 14 3726 0.83 0.41-1.70
 >2.47 14 3597 0.98 0.48-1.98
 Log(IL-6) 0.84 0.54-1.29
1

Excluding individuals with baseline CRP >10 mg/l

2

Adjusted for age, race, enrollment period, diabetes status, current NSAID use, and clinic