. Author manuscript; available in PMC: 2010 Sep 1.

Published in final edited form as: Cancer Causes Control. 2009 Mar 8;20(7):1193–1203. doi: 10.1007/s10552-009-9320-4

Table 3. Associations¹ between C-reactive protein and interleukin-6 tagSNPs and prostate cancer risk by race, adjusted for age, enrollment period, and clinic.

	EAs (n=2,015)			AAs (n=311)
SNP² (position³)	Cases/Cohort	HR	95% CI	Cases/Cohort	HR	95% CI
CRP SNPs
rs3093058 (790)
AT or TT	--			14/94	1.15	0.60-2.22
AA	--			26/206	1.00	Ref
AT	--			12/85	1.09	0.55-2.18
TT	--			2/9	1.74	0.40-7.49
				P_trend=0.56
rs1417938 (1919)
AT or TT	92/1013	1.02	0.75-1.36	9/70	0.88	0.42-1.85
AA	83/921	1.00	Ref	31/230	1.00	Ref
AT	69/830	0.92	0.67-1.27	8/66	0.84	0.39-1.83
TT	23/183	1.38	0.87-2.20	1/4	1.40	0.18-10.98
	P_trend=0.45			P_trend=0.83
rs1800947 (2667)
GC or CC	22/242	1.05	0.67-1.64	2/11	1.10	0.26-4.69
GG	153/1691	1.00	Ref	38/289	1.00	Ref
GC	21/236	1.02	0.65-1.62	2/11	1.10	0.26-4.69
CC	1/6	1.98	0.28-14.21	0/0	--	--
Missing	1			0
	P_trend=0.76			P_trend=0.90
rs1205 (3872)
GA or AA	90/1062	0.89	0.66-1.20	13/102	0.99	0.51-1.94
GG	85/871	1.00	Ref	27/198	1.00	Ref
GA	72/845	0.91	0.67-1.25	11/94	0.90	0.44-1.82
AA	18/217	0.83	0.50-1.38	2/8	2.44	0.56-10.58
Missing	1			0
	P_trend=0.41			P_trend=0.74
rs2808630 (5237)
AG or GG	86/908	1.08	0.80-1.46	16/116	1.03	0.54-1.96
AA	89/1026	1.00	Ref	24/184	1.00	Ref
AG	73/760	1.10	0.81-1.51	16/107	1.12	0.59-2.15
GG	13/148	0.98	0.54-1.75	0/9	0.00	--
	P_trend=0.76			P_trend=0.75

IL-6 SNPs
rs1800796 (1111)
GC or CC	19/194	1.07	0.66-1.72	3/47	0.36	0.11-1.19
GG	156/1740	1.00	Ref	37/253	1.00	Ref
GC	19/192	1.08	0.67-1.74	2/46	0.25	0.06-1.05
CC	0/2	0.0	--	1/1	3.47	0.39-30.96
	P_trend=0.83			P_trend=0.14
rs1800795 (1510)
GC or CC	127/1237	1.44	1.03-2.01	6/50	0.91	0.38-2.17
GG	48/696	1.00	Ref	34/250	1.00	Ref
GC	96/901	1.49	1.05-2.11	5/48	0.79	0.31-2.02
CC	31/336	1.30	0.82-2.04	1/2	4.14	0.53-32.68
Missing	1			0
	P_trend=0.14			P_trend=0.92
rs2069830 (2002)
CT or TT	--			8/31	1.52	0.96-3.31
CC	--			32/259	1.00	Ref
CT	--			7/38	1.44	0.63-3.28
TT	--			1/3	2.51	0.30-20.65
				P_trend=0.27
rs2069837 (2892)
AG or GG	29/319	1.04	0.70-1.56	10/53	1.70	0.82-3.50
AA	146/1613	1.00	Ref	30/247	1.00	Ref
AG	24/295	0.93	0.60-1.44	10/52	1.69	0.82-3.50
GG	5/24	2.46	1.00-6.06	0/1	0.67	0.00--
Missing	2			0
	P_trend=0.48			P_trend=0.17
rs1474347 (2989)
AC or CC				13/93	1.04	0.53-2.03
AA	--			27/207	1.00	Ref
AC	--			10/81	0.90	0.43-1.88
CC	--			3/12	2.05	0.60-7.00
				P_trend=0.61
rs1524107 (3084)
CT or TT				2/33	0.36	0.08-1.51
CC	--			38/267	1.00	Ref
CT	--			2/33	0.36	0.08-1.51
TT	--			0/0	--	--
				P_trend=0.10
rs1554606 (3572)
GT or TT	128/1301	1.25	0.90-1.76	20/161	0.82	0.44-1.54
GG	47/623	1.00	Ref	20/138	1.00	Ref
GT	93/926	1.29	0.90-1.83	15/121	0.81	0.41-1.60
TT	35/375	1.16	0.76-1.83	5/40	0.84	0.31-2.26
Missing	10			1
	P_trend=0.38			P_trend=0.60
rs2069849 (6021)
CT or TT	5/109	0.45	0.19-1.11	9/73	0.86	0.40-1.86
CC	170/1825	1.00	Ref	31/227	1.00	Ref
CT	5/108	0.46	0.19-1.11	8/69	0.81	0.37-1.81
TT	0/1	--	--	1/4	1.67	0.21-12.98
	P_trend=0.05			P_trend=0.84
rs1818879 (7592)
GA or AA	84/990	0.88	0.65-1.19	11/103	0.64	0.32-1.30
GG	91/944	1.00	Ref	29/197	1.00	Ref
GA	70/804	0.91	0.66-1.24	11/95	0.71	0.35-1.44
AA	14/186	0.78	0.44-1.37	0/8	--	--
	P_trend=0.33			P_trend=0.13

P-values are not adjusted for multiple tests.

SNPs associated with CRP and/or IL-6 blood concentrations in the CHS cohort are in bold and underlined.

The CRP and IL-6 SNP positions are relative to GenBank accession numbers AF449713 and AF372214, respectively.

Table 3. Associations1 between C-reactive protein and interleukin-6 tagSNPs and prostate cancer risk by race, adjusted for age, enrollment period, and clinic.

Table 3. Associations¹ between C-reactive protein and interleukin-6 tagSNPs and prostate cancer risk by race, adjusted for age, enrollment period, and clinic.