Table 2.

Summary of PON1 Enzyme Activity by PON1 Polymorphisms in Children at Birth (n=335) and Age 7 (n=268)

PON1		AREasec (U/mL)		CPOased (U/L)		POasee (U/L)
	Frequency (%)	Birth Mean(Range)	7 Years Mean(Range)	Birth Mean(Range)	7 Years Mean(Range)	Birth Mean(Range)	7 Years Mean(Range)
192
QQ	24.4	31.7(3.9–70.9)a	129.5(52.9–246.3)	1811.3(175.3–4397.6)ab	6885.8(2074.8–11181.3)	110.0(13.1–519.7)ab	316.4(119.5–954.7)ab
QR	51.6	32.2(3.8–98.0)	119.9(14.5–184.6)	1974.7(153.9–5255.2)	6985.0(904.2–11195.7)	253.7(7.5–682.1)	881.3(133.6–1444.2)
RR	24.0	36.7(9.7–73.6)	117.6(61.1–190.4)	2334.1(569.3–5159.5)	7321.5(3858.3–11576.7)	408.3(62.1–1017.5)	1461.8(782.0–2504.5)
−108
CC	27.8	42.2(13.9–90.3)ab	138.5(73.3–246.3)ab	2607.6(823.4–4397.6)ab	8286.1(3737.3–11576.7)ab	348.8(38.3–742.8)ab	1218.2(166.0–2504.5)ab
CT	53.2	32.0(3.8–98.0)	119.6(14.5–198.9)	1939.1(153.9–5255.2)	6863.8(904.2–11195.7)	241.9(7.5–1017.5)	844.5(119.5–2005.8)
TT	19.0	23.2(3.9–54.7)	101.7(33.6–159.9)	1389.1(175.3–3409.0)	5734.6(1896.8–7967.2)	157.9(13.1–485.6)	568.2(155.5–1468.2)
All		33.1(3.84–98.0)	121.5(14.5–246.3)	2020.2(4153.9–5255.2)	7035.8(904.2–11576.7)	257.1(7.5–1017.5)	894.2(119.5–2504.5)

In children, the PON1₁₉₂ genotype was significantly associated with POase activity at both time points. Children with the RR genotype had the highest mean POase activities compared to QR and QQ children. The promoter polymorphism, PON1₋₁₀₈, was associated with all three substrate-specific activities at birth and age 7. On average, children with the TT genotype had lower activities than those with the CT and CC genotypes.

^ap_trend for genotype <0.05, determined by Cuzick’s non-parametric test

^bp_trend for genotype significant after Bonferonni correction for multiple testing (n=35 tests, p≤0.001)

^cAREase = arylesterase activity

^dCPOase = chlorpyrifos-oxonase activity

^ePOase = paraoxonase activity