CARTp increases Y2R- and CARTp- immunoreactivity in vagal afferent neurons in fasted rats but has no effect on CB1R, MCH1R and MCH abundance. (A) CB1R immunoreactivity is detected in vagal afferent neurons of rats fasted for 24 h and is decreased by CCK8s (10 nmol, ip, 1 h) but not by CARTp (2 nmol, ip, 1 h). (B) Similar data for MCH and (C) for MCH1R expression. (D) Expression of Y2R is barely detectable in nodose neurons of rats fasted 24 h but is increased by CCK8s (10 nmol, ip, 1 h) and by CARTp (2 nmol, ip, 1 h); (E) similar data for CARTp expression. Representative results from 4–5 rats in each group. Scale bar = 30 µm.