Stability of alternative chemical derivatives. The normalised responses after internal standardisation of alternative glutamate (a) and glucose (b) derivatives are shown. The high agreement of the METAPHOR data [L1], [L2.1], [L2.1 2D], [L3], processed by [M1] is demonstrated. For analysis of the resilient biological matrices or unstable metabolite derivatives, specific stable isotope labelled standards will enhance accuracy. Note that glutamic acid 2TMS was not detectable in [L1]