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Conservation of the amino acid alanine in position 335 (a) and the SH3-binding motif in MED25 (b). Genomic structure, domains, and peptide motifs present in MED25. The von Willebrandt factor type A (vWA) domain and an activator-interacting domain (ACID) were previously verified experimentally [35, 36]. The SH3-binding site result from a computational prediction and its SH3-binding ability has been proven in the present study
