Fig. 6.

Med25 qRTPCR expression analysis in Pmp22 transgenic animals. Wild-type and trembler mice showed similar Med25 expression, whereas Pmp22^tg mice showed an increased and Pmp22^−/− mice a reduced expression (a). CMT (Pmp22^++/+) rats revealed also a significantly increased expression compared to wildtype (b). After progesterone supplementation, similar significant results were obtained, whereas onapristone had no significant effect (c). Med25 dosage is strictly correlated with Pmp22 dosage in Pmp22^−/− and Pmp22^tg mice and Pmp22^++/+ rats (n = number of animals examined)