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. Author manuscript; available in PMC: 2010 Mar 30.
Published in final edited form as: Mol Cell. 2007 Aug 3;27(3):353–366. doi: 10.1016/j.molcel.2007.06.024

Figure 7. Active and Repressive Chromatin States Intersperse without Overlap.

Figure 7

Mutually exclusive active and repressive chromatin modifications that mark the expressed and silent Air and Igf2r genes that lie 28 kb apart are illustrated for the maternal (MAT) and paternal (PAT) chromosomes. The expressed Air and Igf2r promoters lack repressive modifications and are marked by H3K4me3, H3K4me2, and H3K9Ac. DHS sites are present on both parental chromosomes, but only those that lie within 20 kb of the expressed promoters are marked by active modifications (H3K4me2 and H3K9Ac, but not by H3K4me3). The silent Air and Igf2r promoters lack active modifications and are marked by focal HC peaks of H3K9me3, HP1, and H4K20me3 that resemble heterochromatin defined at centromeres, telomeres, and the inactive X chromosome. Note that these HC peaks do not impede transcript elongation from the expressed Igf2r and Air promoters.

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