Table 2.

Comparison of different methods for the prediction of critical residues in protein interfaces using BID dataset

Method	Precision (P)	Recall (R)	F1 score
PCRPi (Ab+)a	0.79	0.64	0.71
FoldXb	0.75	0.36	0.49
Robetta-Alac	0.63	0.57	0.60
KFCc	0.51	0.36	0.42
KFC-Ac	0.53	0.48	0.51
LDAc	0.72	0.57	0.64
Tuncbag et al. (16)c	0.73	0.59	0.65

^aPredictions were performed on the default expert BN (Figure 2A) using the Ab+ dataset as training set previous exclusion of 1fcc protein complex.

^bValues were obtained running FoldX(10) with default parameters and a ddG_binding cut-off of 2.0 Kcal mol⁻¹ (i.e. residues were considered critical if predicted ddG_binding ≥ 2.0 Kcal mol⁻¹).

^cPrecision, recall and F1 score values taken from Tuncbag et al. (16).