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The C-terminal domains of Rpb5 and RpoH are very similar. Superposition of the tertiary structures of subunits Rpb5 from yeast based on the RNAP II crystal structure (N-terminal domain coloured in orange and the C-terminal domain in red; PDB ID: 1I3Q; 8) and of the archaeal subunit H from S. solfataricus (coloured in blue; PDB ID: 2PMZ; 9) generated using DaliLite (45). The R.M.S. value of this alignment is 1.1 Å.
