Figure 1.

Multiple sequence alignment of TERT motif 3. (A) Schematic of domain and motif organization of human TERT protein. Motif 3 (red) and the conserve RT motifs 1, 2 and A–E (cyan and blue) are colored. (B) Sequence alignment of TERT motif 3 from vertebrates, invertebrates, fungi, plants and ciliates. Shading indicates a minimum of 55% identity (dark cyan, red and blue) and 55% similarity (light cyan, red and blue) conservation. The degree of identity conservation with the human sequence at each residue is shown below the sequence alignment. No conservation determined where more than two sequences had gaps present. Darker shading indicates greater identity conservation with the human sequence (<30% light, 30–60% medium and >60% dark).