Table 1. Characteristics of 38 primary T-ALL samples showing PHF6 inactivation.

							PHF6 lesion
ID	Sex	Age	WBC (×109/l)	Immuno-phenotype	Genetic subtype	NOTCH1	Type of alteration	Predicted protein	Germline/somatic
	PHF6 deletions
1	M	Ped	77	Cortical	TLX3	mut	Deletion (0.55 Mb)		NA
2	M	Ped	46	Pre-T	TLX3	wt	Deletion (0.23 Mb)		NA
3	M	Ped	31	Pre-T	TLX3	NA	Deletion (1.50 Mb)		NA
4	M	Ped	2	Pre-T	unknown	NA	Deletion (0.27 Mb)		NA
5	M	Ped	NA	Cortical	HOXA	NA	Deletion (1.90 Mb)		Somatic
6	M	Ped	NA	Cortical	unknown	NA	Deletion (0.20 Mb)		Somatic
7	M	Ped	NA	Cortical	TLX1	NA	Deletion (0.08 Mb)		Somatic
8	M	Adult	NA	Pre-T	Unkn	NA	Deletion (0.11 Mb)		NA
	PHF6 mutations
9	M	Ped	185	Cortical	TLX3	wt	Nonsense	p.G122X	NA
10	M	Ped	417	Pre-T	TLX3	mut	Nonsense	p.R116X	NA
11	F	Ped	280	Pre-T	TLX1	mut	Frameshift	p.F172fs	NA
12	M	Ped	405	Pre-T	TLX3	mut	Frameshift	p.Y303fs	NA
13	M	Ped	159	Pre-T	TLX1	mut	Nonsense	p.K235X	NA
14	M	Ped	500	Pre-T	TLX3	mut	Frameshift	p.A41fs	NA
15	M	Ped	347	Cortical	HOXA	mut	Nonsense	p.K274X	NA
16	M	Ped	129	Cortical	unknown	mut	Frameshift	p.D333fs	NA
17	M	Ped	174	Cortical	TLX3	mut	Nonsense	p.R225X	NA
18	M	Ped	27	Cortical	TLX1	wt	Nonsense	p.R116X	NA
19	M	Ped	310	Cortical	TAL1	mut	Missense	p.C283R	NA
20	M	Ped	189	Cortical	TAL1	mut	Frameshift	p.C28fs	NA
21	M	Adult	170	Cortical	TLX3	wt	Frameshift	p.H44fs	NA
22	M	Adult	21	Cortical	TLX1	mut	Frameshift	p.H43fs	Somatic
22	M	Adult	21	Cortical	TLX1	mut	Frameshift	p.H43fs	Somatic
23	M	Adult	NA	Pre-T	TLX3	mut	Frameshift	p.T98fs	Somatic
24	M	Adult	14	Pre-T	TLX3	wt	Frameshift	p.Y105fs	NA
25	M	Adult	28	Mature	TLX3	wt	Frameshift	p.S158fs	NA
26	M	Adult	NA	Cortical	TLX3	mut	Missense	p.C215Y	NA
27	M	Adult	NA	Pre-T	Unkn	mut	Missense	p.C215F	NA
28	M	Adult	31	Cortical	Unkn	mut	Missense	p.C215Y	NA
29	M	Adult	NA	Mature	TLX3	mut	Missense	p.T300A	Somatic
30	M	Adult	21	Cortical	TLX1	wt	Missense	p.A311P	NA
31	M	Adult	30	Mature	Unkn	wt	Missense	p.C280Y	NA
32	M	Adult	23	Cortical	Unkn	wt	Missense	p.H329R	Somatic
33	M	Ped	NA	NA	TAL1	NA	Nonsense	p.R257X	Somatic
34	M	Ped	NA	NA	TLX1	NA	Frameshift	p.S191fs	Somatic
35	M	Adult	NA	NA	TLX1	NA	Missense	p.C215F	Somatic
36	M	Adult	NA	NA	TLX1	NA	Nonsense	p.Y303X	NA
37	M	Adult	NA	NA	Unkn	NA	Nonsense	p.R274X	NA
38	M	Adult	NA	NA	Unkn	NA	Frameshift	p.H135fs	NA

Ped, pediatric; NA, not available; mut, mutated; wt, wild-type.