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. Author manuscript; available in PMC: 2011 Jan 1.
Published in final edited form as: Ocul Surf. 2010 Jan;8(1):8–17. doi: 10.1016/s1542-0124(12)70213-6

Figure 3. Functions of mucin-type O-glycans at the ocular surface.

Figure 3

Cell-surface O-glycans at the apical membrane of epithelial cells bind multiple galectin-3 oligomers to form a highly organized cell-surface barrier. This barrier, in conjunction with tight junctions which seal the space between adjacent cells, contributes to protection of the epithelia against noxious molecules and pathogens. Cell-surface O-glycans also confer a disadhesive character to the ocular epithelia that limits pathogen colonization and prevents the tarsal conjunctival epithelial surface of the eye from adhering to the cornea during blinking or sleep. Secreted O-glycans in the tear film contribute to retention of water and lubrication of the surface of the eye, and facilitates the clearing and discharge of pathogens from the ocular surface.