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. Author manuscript; available in PMC: 2010 Mar 30.
Published in final edited form as: Hematology Am Soc Hematol Educ Program. 2009:353–361. doi: 10.1182/asheducation-2009.1.353

Figure 1. The NOTCH1 signaling pathway.

Figure 1

Interaction of the NOTCH1 receptor with Delta-like and Jagged ligands expressed on the surface of a neighbor cells triggers the proteolytic cleavage of the receptor, first by an ADAM metalloprotease (S2 cleavage) and subsequently by the γ-secretase complex (S3 cleavage), which releases the intracellular domains of NOTCH1 (ICN1) from the membrane. ICN1 translocates to the nucleus and interacts with DNA via the RBPJ/CSL DNA binding protein and recruits the MAML1 coactivator to activate the expression of NOTCH1 target genes.