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. Author manuscript; available in PMC: 2010 Apr 1.
Published in final edited form as: Trends Genet. 2009 Sep 30;25(10):443–454. doi: 10.1016/j.tig.2009.08.002

Figure I.

Figure I

Strategies for duplication detection (WSSD and WGAC). (a) A schematic representation of the whole-genome shotgun sequence detection (WSSD) method to detect recent duplications. In short, whole-genome shotgun reads are mapped against a reference assembly and duplication is detected by the excess of read-depth. Thresholds for duplication detection are estimated from known single-copy BACs. (b) A whole-genome assembly comparison (WGAC) strategy where the genome is segmented, repeats are extracted and the remaining genome segments are compared to identify high identity pairwise alignments.