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. Author manuscript; available in PMC: 2010 Aug 20.
Published in final edited form as: Drugs. 2009 Aug 20;69(12):1555–1623. doi: 10.2165/11317030-000000000-00000

Fig. 2.

Fig. 2

Regulation of the RND superfamily Mex transporters of P. aeruginosa. The efflux systems are shown in the light blue blocks with the respective transcriptional units presented in the solid grey lines. All regulators are shown in the green boxes, and their functions as repressor or activator are indicated, respectively, in the green or orange dotted arrows. The inverse relationship between MexAB-OprM expression and MexCD-OprJ/MexEF-OprN expression is marked by a double arrowed line. Interaction of the regulators (MexR or MexT) with the modulators (ArmR or MexT) is denoted by the double arrowed dotted lines. See text and relevant references for details of the regulation. MDA=membrane-damaging agents; QS AIs= quorum-sensing autoinducers.