Skip to main content
. Author manuscript; available in PMC: 2010 Aug 20.
Published in final edited form as: Drugs. 2009 Aug 20;69(12):1555–1623. doi: 10.2165/11317030-000000000-00000

Table 2.

MFS, MATE, SMR and ABC multidrug efflux transporters in bacteria reported or further characterized since 2003

Transporter family/Organism Efflux pump Regulator (Family) Substratesa References
Major Facilitator Superfamily (MFS)
Acinetobacter baumannii SmvA (A1S_2057) ? EM, MV, QAC [299]
Bacillus subtilis Bmr3 ? FQ, PU [403, 744]
LmrB LmrA (TetR) DR, FQ, LC, PU [404, 405]
MdtP MdtR (MarR) AT, FU, NO, SM [408]
Bordetella bronchiseptica CmlB1 ? CM [745]
Clostridium difficile Cme ? EB, EM, SA [399]
Clostridium saccharolyticum Tet(40) ? TC [402]
Enterobacter aerogenes QepA (plasmidborne) ? FQ [184]
Enterococcus faecium EfmA ? DP, FQ, TPP [470]
Escherichia coli Mef(B) (plasmidborne) ? ML [533]
QepA, QepA2 (plasmidborne) ? FQ [23, 160, 161]
Helicobacter pylori Hp1181 ? Unknown [746]
Klebsiella pneumoniae KmrA (Ec) ? AC, DP, EB, HO, MV, TPP [193]
Listeria monocytogenes Lde ? AC, BC, EB, FQ [421, 424, 425]
MdrL LadR Unknown [422]
MdrM MarR Unknown [423]
MdrT TetR Unknown [423]
Mycobacterium smegmatis LfrA LfrR (TetR) AC, EB, FQ [514, 528]
Salmonella Typhimurium EmrAB ? DC, NA, NO [172]
MdfA ? CM, DR, NF, TC [172]
SmvA-OmpW ? MV [747]
Serratia marcescens SmfY ? AC, BC, DP, EB, NF [202]
Staphylococcus aureus MdeA ? BC, DQ, EB, FU, HO, MU, NO, QAC, TPP, VM [428, 748]
NorB MgrA (MarR), NorG (GntR) CT, EB, FQ [432–434, 436, 749]
NorC MgrA (MarR) FQ [432]
SdrM (Ec) ? AC, EB, NF [431]
Tet38 MgrA (MarR) TC [433, 436]
Staphylococcus lentus FexA (plasmidborne) ? CM, FP [438]
Stenotrophomonas maltophilia Smlt0032 ? MC [306]
Smlt1528-1529-1530 ? Unknown [306]
Streptococcus agalactiae MefB, MefG ? MC [750]
Tet42 TetR TC [751]
Streptococcus suis SmrA ? FQ [752]
Vibro cholerae VceCAB VceR (TetR) CCCP, DC, NA, PA, PC [1, 210]
Xanthomonas albilineans AlbF ? AB [753]
Multidrug and Toxic Compound Extrusion (MATE) Family
Acinetobacter baumannii AbeM ? AC, AG, DN, DR, FQ, HO, RG [298]
Brucella melitensis NorMI ? AC, BB, FQ, GM, TPP [348]
Clostridium difficile CdeA ? AC, EB [398]
Erwinia amylovora NorM ? AP, BB, EB, CV, FQ, KM, MB, PH [754]
Haemophilus influenzae HmrM ? AC, BB, DC, DN, DP, DR, EB, HO, TPP [322]
Neisseria gonorrhoeae NorM ? CC [339]
Neisseria meningitidis NorM ? CC [339]
Pseudomonas aeruginosa PmpM ? AC, BC, EB, TPP [263]
Ralstonia solanacearum DinF ? AC, AP, BB, EB, TPP [595]
Salmonella Typhimurium MdtK ? AC, DR, NF [172]
Staphylococcus aureus MepA MepR (MarR) CT, EB, FQ, MDB, TG [429, 430, 666]
Vibrio cholerae NorM ? EB, FQ [217]
VcmB, VcmD, VcmH, VcmN ? AG, EB, FQ, HO [215]
VcrM ? AC, DP, EB, HO, RG, TPP [213]
Vibrio parahaemolyticus VmrA ? AC, DP, EB, TPP [755]
Small Multidrug Resistance (SMR) Family
Acinetobacter baumannii Smr (A1S_0710) ? DC, SDS [299]
Escherichia coli MdtJI DC, SDS, SP [153]
Serratia marcescens SsmE ? AC, EB, NF [203]
Staphylococcus aureus SepA ? AC, BC, CH [435]
ATP-Binding Cassette (ABC) Superfamily
Bacillus subtilis YtsCD YtsA BA [756]
YvcC (BmrA) ? AA, DR, HO [409]
Bifidobacterium breve AbcAB ? NI, PM [507]
Enterococcus faecalis EfrAB ? AC, DA, DP, DR, FQ, TC, TPP [463]
Enterococcus faecium MsrC ? MC, QP [467, 468]
Escherichia coli YojI Lrp MJ [150, 151]
Lactococcus lactis LmrCD LmrR (PadR) CL, DN, EB, HO, RG [451–454]
Mycobacterium bovis BCG Bcg0231 ? AP, CM, SM, VC [757]
Mycobacterium tuberculosis Rv0194 ? AP, EM, NO, VC [757]
Rv1258C (Tap) ? FQ, RF, TC [1, 523]
Rv2686c- ? FQ [521]
Rv2687c-
Rv2688c
Neisseria gonorrhoeae MacAB ? ML [338]
Oenococus oeni OmrA ? ML, SL [758, 759]
Salmonella Typhimurium MacAB ? EM [172]
Serratia marcescens SmdAB ? DP, HO, NF, TC [204]
Staphylococcus aureus AbcA MgrA (MarR), NorG (GntR) BL [434, 760]
Sav1866 ? EB, HO, TPP [101]
Stenotrophomonas maltophilia Smlt1537-1538-1539 ? MC [306]
Smlt2642-2643 ? MC [306]
Streptococcus pneumoniae PatA, PatB ? FQ [483–486]
SP2073/SP2075 ? AC, EB, FQ, NO [487]
Spr0812/Spr0813 BA [488]
Vibrio chlolera VcaM ? DN, DP, DR, FQ, HO, TC [214]
a

AA=7-aminoactinomycin D; AB=albicidin; AP=ampicillin; AT=actinomycin D; BA=bacitracin; BB=berberine; BC=benzalkonium chloride; CC=cationic compounds; CCCP=carbonyl cyanide m-chlorphenylhrazone; CH= chlorhexidine; CL= cholate; CM=chloramphenicol; CT=cetrimide; DA=daunorubicin, DN=Daunomycin; DP=4′,6-diamidino-2-phenylindole; DQ=dequalinium chloride; DR=doxorubicin; EB=ethidium bromide; EM=erythromycin; FP=florphenicol; FQ=fluoroquinolones; FU=fusidic acid; GM=gentamicin; HO=Hoechst 33342; KM=kanamycin; LC=lincosamides; MB=methylene blue; MC=macrolides; MDB=monovalent and divalent biocides; MJ=microcin J25; ML=metal salts; MU=mupirocin; MV=methyl viologen; NF=norfloxacin; NI=nisin; NO=novobiocin; PA=phenymercuric acetate; PC=pentachorophenol; PH=Phloretin; PM=polymyxin B; PU=puromycin; QAC=quaternary ammonium compounds; QP=quinupristin; RF=rifampin; SA=safranin; SL=Sodium laureate; SM=streptomycin; SP=spermidine; TC=tetracyclines; TPP=tetraphenylphosphonium; VC=vancomycin; VM=virginiamycin; VR=vancoresmycin; ?=the regulators remain unknown or no regulator genes linked to the transporter structural gene(s) are identified.