Table 5.

Synopsis of transgenic models for tauopathies

Tg Name	Species	Tau isoform	Mutation(s)	Promoter
JNPL3 [59]	Mus musculus	h4R0N	P301L	mPrP
rTg4510 [60]	M. musculus	h4R0N	P301L	CamKII-driven Tta/TetO^a
htau [61]	M. musculus	All 6 human isoforms^b	None	hMAPT
Tg lines 7, 43 [62]	M. musculus	h3R0N	None	mPrP
pR5 [63]	M. musculus	h4R2N	P301L	mThy1.2
ALZ7 [64]	M. musculus	h4R2N	None	hThy1
ALZ17 [65]	M. musculus	h4R2N	None	mThy1.2
Tg214 [66]	M. musculus	h4R2N	V337M	PDGF
R406W [67]	M. musculus	h4R2N	R406W	CamKII
T-279 [68]	M. musculus	h4R2N^c	N279K	MAPT
Tau (P301S) [69]	M. musculus	h4R0N	P301S	mThy1.2
PS19 [70]	M. musculus	h4R1N	P301S	mPrP
Tau4R2N [71,72]	M. musculus	h4R2N	None	mThy1.2
GFAP/tau Tg [72]	M. musculus	h4R1N	None	GFAP
K3 [73]	M. musculus	h4R0N	K369I	mThy1.2
nWT Tg [74]	M. musculus	h4R1N	None	CNP
PL Tg [74]	M. musculus	h4R1N	P301L	CNP
Tau RD mice [75]	M. musculus	h4R^d	deltaK280	CamKII-driven Tta/TetO^a
Tau RD mice [75]	M. musculus	h4R^d	deltaK280 + I277P + I308P	CamKII-driven Tta/TetO^a
3 × Tg–AD [76]	M. musculus	h4R0N	P301L^e	mThy1.2
Tg30 [77]	M. musculus	h4R1N	P301S + G272V	Thy1
gl-Tau^wt [78]	Drosophila melanogaster	h4R0N	None	G1
(UAS)Tau^wt [79]	D. melanogaster	h4R0N	None	UAS^f
(UAS)Tau^R406W [79]	D. melanogaster	h4R0N	R406W	UAS^f
(UAS)Tau^V337M [79]	D. melanogaster	h4R0N	V337M	UAS^f
N-1 [80]	Caenorhabditis elegans	h4R1N	None	aex-3
T301^L [80]	C. elegans	h4R1N	P301L	aex-3
T337^M [80]	C. elegans	h4R1N	V337M	aex-3
Tg(eno2:Tau)^Pt406 [81]	Danio rerio	h4R0N	None	eno2

Inducible Tet-OFF system.

Created on MAPT (−/−) background.

Tau mini-gene construct.

Only contain microtubule repeat domain (aa 244–372).

Also contains mutated hPSEN1 (M146V) and hAPP (swe) genes.

Pan neuronal (elav-GAL4) or cholenergic specific (cha-GAL4) expression.